Structural Kinome

The Structural Kinome Site is a centralized platform dedicated to the structural and functional exploration of the human kinome. Our mission is to integrate, visualize, and analyze the kinase three-dimensional structures to advance understanding of their catalytic mechanisms, conformational diversity, and ligand interactions. By curating experimentally determined and computationally modeled kinase structures, it serves as a bridge between structural biology, databases, AI models, and drug discovery. Researchers can use it to identify active and inactive inhibitors, explore covalent and non-covalent binding sites, and compare structural features across kinase families, supporting applications in kinase inhibitor design, polypharmacology profiling, and disease-associated target analysis, offering a foundation for systematic, structure-guided studies in chemical biology and precision medicine.