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Names
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Descriptions
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Downlowd (Preparing, please wait)
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Kinase Domain Structures
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The Kinase Domain Structures Database is a comprehensive resource compiling
3D structures of kinase domains. It provides detailed structural information,
including domain-specific features, and is designed for researchers in structural kinase landscape.
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Ligand-binging Kinase Complexes
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This collection features experimentally determined kinase structures bound to
small-molecule ligands. Each complex provides insight into binding modes, active site
interactions, and conformational changes upon ligand engagement. The resource supports structure-based
drug design, polypharmacology studies, and kinase-targeted therapeutic research, enabling researchers to explore how
ligands modulate kinase activity at the molecular level and AI model training
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Covalent-Inhibitor-binding Kinase Complexes
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This collection showcases kinase structures bound to covalent inhibitors,
highlighting specific reactive residues and binding modes. By capturing the molecular details of
covalent interactions, it serves as a valuable resource for covalent drug design, mechanistic studies,
and structure-guided inhibitor optimization. Researchers can explore how covalent binding affects kinase conformation, selectivity,
and activity, facilitating the development of highly specific therapeutic agents.
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Covalent kinase inhibitors
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Covalent kinase inhibitors are small molecules designed to form a stable,
irreversible bond with specific residues in kinase active sites. This covalent interaction enhances potency and selectivity,
providing a powerful strategy for targeting disease-associated kinases. The study of these inhibitors in structural complexes helps
guide drug design, mechanistic understanding, and the development of next-generation kinase-targeted therapies.
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