Structural Kinome Hub: Kinases, Inhibitors, and Interaction Landscape

The Structural Kinome Hub is a comprehensive resource of kinase domain structures, highlighting covalent inhibitors with their warheads, nucleophiles, and binding profiles across the kinome. It is organized into four specialized components: the Kinase Domain PDB database (KPDB), the Kinase Ligand-binding PDB database (KLPDB), the Apo Kinase PDB database (AKPDB), and the Covalent Inhibitor-binding Kinase PDB database (CIKPDB). , along with an online navigable interface for exploring covalent kinase inhibitor (CKI) binding (shown below).

Latest update: 2025-June-28

Number of KPDB (PDB IDs): 6969

Number of Covered Kinases: 355 (Human:311; Mouse: 42; Chicken: 2)

Number of KLPDB (PDB IDs): 6122

Number of AKPDB (PDB IDs): 847

Number of CIKPDB (PDB IDs): 321 (Details below)

Download the databases (txt format): KPDB  , KLPDB  , AKPDB  , CIKPDB

Reference: We will update once published